After an experimental drug trial goes horribly wrong, the surviving test subjects have to fight off sleep, and each other, to stay alive.。查理·布朗森(戴克斯·夏普德 Dax Shepard 饰)是专门帮人跑路的汽车司机,向来拿钱办事,尽量不卷进是非中。可一次意外却还是让他不可避免地成为了别人争相想要灭口的目标,于是他只好接受警方为他提供的证人保护计划。但为了女友安妮(克里斯汀·贝尔 Kristen Bell 饰)能够得到一份梦寐以求的理想工作,继而摆脱小镇生活,去大城市发展。他决定不顾劝阻,执意开车送安妮前往洛杉矶。由此,他们不但受到了以兰迪(汤姆·阿诺德 Tom Arnold 饰)为首的联邦调查局的追捕,而且查理之前的犯罪同伙(布莱德利·库珀 Bradley Cooper 饰),也加入到了这场混战当中…… 一场公路之旅,很快就向着一个异常让人难堪的复杂方向飞速地发展着,既疯狂又棘手……。克里斯与西塞莉是一对年轻的爱人,一个是国际记者,一个是剧场演员,他们挣扎于要兼顾爱情还是要冲刺事业中,爱得很深,又非常骄傲,两个常年分居,独自生活……(by波迪与鹅) In New York, the rookie newsman Christopher "Chris" Tyler dreams on becoming a famous journalist. When his girlfriend Cicely spends a couple of days with him, they decide to get married and Cicely leaves college. Chris's best friend Tommy Abbott is his best man and becomes a family's friend. Chr...。