Paul Slippery (Hugh Laurie), a forty-something doctor, lives with his wife Estelle and three sex-obsessed sons Rory, Daniel and Edwin in the west London suburb of Putney. On top of coping with family pressures and a mid-life crisis, Paul discovers his unusual ability to hear other peoples' inner thoughts.。一次濒死体验、对他父亲的启示,以及以由他的名字命名的三明治似乎改变了拉里。 但当拉里得知自己的好友理查德·刘易斯卧床不起,并需要进行肾脏移植手术时,尽管拉里和杰夫都是刘易斯的好搭档,却谁都不愿意轻易放弃他们宝贵的器官。。